Neurotropic and modulatory effects of insulin-like growth factor II in Aplysia
نویسندگان
چکیده
منابع مشابه
Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.
Overlapping recombinant clones that encompass the insulin-like growth factor (IGF) I and II genes have been isolated from a human genomic DNA library. Each gene is present once per haploid genome; the IGF-I gene spans greater than 35 kilobase pairs (kbp) and the IGF-II gene is at least 15 kbp. The exon-intron organization of these genes is similar, each having four exons, which is one more than...
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We have previously shown that insulin and the insulin-like growth factors share some important neurotrophic properties with nerve growth factor (NGF), including the capacity to enhance neurite formation. In this study, we have examined the effects of these neuritogenic agents on the expression of genes coding for important cytoskeletal proteins of axons and dendrites. Insulin specifically and c...
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Purpose: The limited availability of donor sites for nerve grafts continues to stimulate research toward finding suitable alternatives. Material and Methods: In the following study, the effects of direct administration of Nerve Growth Factor (NGF), Insulin - Like Growth Factor - I (IGF-I) , or / and collagen gel into Polyvinylidene Fluride (PVDF) gap was tested in a rat sciatic nerve model. A ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-50923-5